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Activity of L-Mesitran Ointment and Soft against (antibiotic resistant) bacteriae
The University hospital of Maastricht researched the antibacterial activity of L-Mesitran Ointment and Soft. The department of Medical Microbiology tested the activity of both products against clinical isolates of Staph. aureus, Ps. aeruginosa, Kl. pneumoniae and E. Coli. All bacteriae were antibiotic resistant and Kl. pneumoniae and E. Coli were ESBL producing strains. The products were tested using controls and comparisons against Manuka and another honey product (available in Holland). Results: L-Mesitran Soft showed to have the highest antibacterial activity against all the bacteriae at the lowest dilution, followed by L-Mesitran Ointment.
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Activity of honey against wound infected bacteria

Summarised below are results from published work carried out by the Honey Research Unit and collaborators, using standardised honeys of average-level antibacterial potency (as are available commercially). The honeys used were a manuka honey (with its antibacterial component unique to honeys from Leptospermum species) and another honey that had the usual type of antibacterial activity due to enzymically produced hydrogen peroxide.
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Efficacy of honey Pseudom J Burn Care Rehabil 2002 Nov
We tested the sensitivity of 17 strains of P. aeruginosa isolated from infected burns to two honeys with different types of antibacterial activity, a pasture honey and a manuka honey, both with median levels of activity. All strains showed similar sensitivity to honey with minimum inhibitory concentrations below 10% (vol/vol); both honeys maintained bactericidal activity when diluted more than 10-fold.
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Journal of Applied Microbiology The sensitivity to honey of Gram-positive cocci
Aims: To determine the sensitivity to honey of Gram-positive cocci of clinical significance in wounds and demonstrate that inhibition is not exclusively due to osmotic effects. Conclusions: The inhibition of bacteria by honey is not exclusively due to osmolarity. For the Gram-positive cocci tested, antibiotic-sensitive and -resistant strains showed similar sensitivity to honey.
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The potential for using honey to treat wounds infected with MRSA and VRE
The antibacterial potency of honey of average level activity is well in excess of that needed to stop the growth of MRSA and VRE. Since honey is of proven effectiveness in clearing wounds of infection with other bacteria, and it gives many other benefits as a wound dressing material, there is good justification for trying it for the treatment of wounds infected with MRSA and VRE.
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Case study: Mesitran - Chronische laesie, Pseudomonas/E. agglomerans
De antibacteriële werking van honing producten is reeds eerder gepubliceerd (Milias, 2008), maar in dit geval bleek ook E. agglomerans gevoelig voor de honingzalf behandeling. Binnen de afdeling chirurgie van het ziekenhuis heeft deze therapie bewezen van grote waarde te zijn voor de behandeling van (geïnfecteerde) wonden zonder een beroep te hoeven doen op antibiotica. De producten zijn zonder bijwerkingen, gemakkelijk en patiëntvriendelijk toe te passen.
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